Eucommia Leaf Extract

Eucommia ulmoides leaves is one kind of natural Chinese herbal medicine feed additives, chlorogenic acid as its main constituents has the functions of bacteriostat, anti-stress, antioxidant, eliminate free radicals, promote growth and improve the meat quality.

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Natural Extract

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susan.lee@rengty.com

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Eucommia Leaf Extract

Description

Active Ingredient

Chlorogenic acid: 5% min.
Polysaccharide: 20% min.
Flavonoid: 8% min

Specification

Specification	Eucommia Leaf Extract
Chlorogenic acid	≥ 5%
Polysaccharide	≥ 20%
Flavonoid	≥ 8%
Appearance	Light yellow to brown powder
particle size	More than 90% pass through the sieve of 1.25 mm
Aroma	It should have slight fragrance,taste is slightly sweet
Loss on drying	≤10%
Arsenic (As)	≤10.0 mg/kg
Heavy metal (Pb)	≤30.0 mg/kg

Function of active ingredient

Chlorogenic acid

1.Broad spectrum antibacterial: especially towards gram-positive bacterium, like staphylococcus aureus
2.Antiviral function: stop the duplication of virus by restrain the activity of neuraminidase
3.Antioxidant: contain amount of R-OH which can restrain free radicals, release hydroxyl radicals and superoxide anion free radicals , improve the activity of endogenous antioxidant enzymes.

Polysaccharide

1.Improve specific-immunity, active T cell and lymphocyte B cell;
2.Increase the breading of beneficial bacterium , as polysaccharide can the food of them
in intestine.
3.Release hydroxyl radicals and superoxide anion free radicals

Flavonoid

1.Improve antioxidant ability by releasing hydroxyl radicals and superoxide anion free radicals
2.As one plant estrogenic , Flavonoid can improve the reproduction performance.

Mechanism

1. Broad-spectrum bacteriostasis

There is a significant inbibitional effect for a variety of bacteria by combined action of Chlorogenic acid, flavonoids and other compound. Vitro antibacterial test results show that minimum inhibitory concentration (mic) of staphylococcus aureus, beta streptococcus is 0.0625g/ml; For minimal inhibitory concentrations (mic) of escherichia coli, salmonella typhi were 0.5g/ml and 0.25g/ml, mechanism for noncompetitive inhibition of bacteria arylamine acetyltransferase, so that the arylamine in the bacterium body is accumulated, the metabolism of bacteria is disorder, then the bacteria can't normal growth and reproduction.

2. Antioxidation, eliminate the free radical

Chlorogenic acid is an effective phenolic antioxidant, its antioxidant capacity is better than coffeic acid, para hydroxy benzoic acid, ferulic acid, syringic acid, butyl hydroxy anisol (BHA) and tocopherol. Mechanism is that Catechol Hydroxyl structure in Chlorogenic acid which can increase the electron cloud density on the hydroxyl group, and also can form intramolecular hydrogen bond to reduce bond energy of O-H, Phenolic hydroxyl group on the hydrogen reaction is easy to occur which means to have strong antioxidant capacity.

3. Protecting liver and gallbladder

From the animal experiment, Chlorogenic acid has obvious protection functions on the liver injury that caused by Carbon tetrachloride (CCl4), acetaminophen and Cadmium, lower the severity of the liver pathological damage obviously which reduced the number of necrosis or rate of necrosis occurred.

Mechanism:

Firstly, by inhibiting cytochrome P-450 drug enzyme metabolic system, induce of glucuronic acid of liver combine desmoenzyme activity, strengthen the combined metabolism of acetaminophen glucuronic acid which can enhance the detoxification metabolism of the acetaminophen in the body, reduce acetaminophen toxic metabolites;
Secondly, induce liver to combine plenty of metal thiol protein(MT) , the MT can combine Cadmium, which can reduce Cadmium distribution of macromolecular protein in nucleus, mitochondria, microsome and cytoplasm, thus reducing cadmium toxicity of liver cell;
Thirdly, can promote bile secretion, accelerate the excretion of toxins.

4. Stimulate the gastrointestinal digestion system

Significantly increase on pharmacological effects in gastrointestinal peristalsis and promoting the gastric secretion, which can improve the animal digestion and nutrients absorption, improve the utilization rate of nutrients, then promote animal growth, improve the production performance.

Functions of products

1.Prevent and treat disease, it can kill staphylococcus aureus, streptococcus, Coli, some parasites and virus, prevent and treat some acute gastrointestinal bacterial disease and coccidiosis.
2.Antibacterial and anti-virus function , replace part of antibiotics , like bacitracin zinc and flavomycin.
3.Endogenous antioxidant, eliminate the free radicals,improve immunity and enhance body resistance.
4.Stimulate the gastrointestinal digestion system, improve digestion, promote feed intake, stimulate the secretion of bile and pancreatic fluid, enhance the activity of digestive enzyme.
5. Improve muscle strength, decrease muscle fiber roughness and body fat content, to improve the flavor and water holding capacity of meat.
6. Improve reproductive performance of and the growth performance.
7. Protect the liver and gallbladder

Application and dosage

This product is suitable for all animals such as pig, poultry, ruminant and aquatic animal, recommended dosage as follow:

Animal Species	Dosage (g/ton of feed)
Poultry	80-150
Piglet	150-250
Big pig	80-100
Sow	200-300
Fish	150-200
Shrimp	250-300
Crab	120-150
Ruminant	100-200

Remark: Eucommia Ulmoides Extract can be extra added, or used with antibiotics together, it can replace part of antibiotics of the feed, such as zinc bacitracin, flavomycin, etc.

Packaging and storage

Sample	20g/bag, 200g/bag, 300g/bag, 500g/bag, 1kg/bag, 2kg/bag, 5kg/bag
Packaging	20kg/drum or as requirements
Pallet	If 20kg/drum, 320kg/16drum/pallet
Container	One 20'GP can contain 9-10 tons if bag
Storage	Stored 24 months sealed in a cool, dry and airy place away from light, heat and dampness.

Delivery

Port of loading: Qingdao or any port of China as requirements
Delivery time: 10-20 days shipment after signed contract

By Express	By Air	By sea	By land
Suitable for under 50kg Fast: 3-7 days High cost Door to door service Easy to pick up the goods	Suitable for more than 50kg Fast: 3-7 days High cost Port to port service Professional broker needed	Suitablefor more than500kg Slow: 7-45 days Low cost Port to port service Profissional broker needed	Suitable for more than 500kg When by sea can not arrive at you, you can select land transportation, by train or by motor

General speaking, EMS, TNT, DHL, UPS by express, by air and by sea is main shipping terms.
By express for quantity less than 50kg cargo, also called DDU service
By sea for quantity over 500kg
By air is available for above 50kg
For high value products, please select air shipping or DHL express for safe
If the cargo quantity is more than 500kg, but by sea can not arrive at you, please select land transportation, by train or by motor.

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